Structural variants in the CCL3L1 gene
In the paper ‘The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility’ (Gonzalez et al Science. 2005 Mar 4; 307(5704):1434-40) it is shown that a higher copy number of the CCL3L1 (Chemokine (C-C motif) ligand 3-like 1) gene is associated with lower susceptibility to HIV infection.
(a) Find the human CCL3L1 gene.
(b) Have any CNVs been annotated for this gene? Note: In Ensembl, CNVs are classified as structural variants.
(a) Go to the Ensembl homepage. Select Search: Human and type ccl3l1 in the search box. Click Go. Click on CCL3L1 (Human Gene) at the top.
(b) Click on Structural Variation in the side menu.
Yes, CNVs have been annotated for this gene by multiple studies, as indicated by the many bars in the larger and smaller structural variants tracks in the display. Details are given in the table below the display.
Note: Can you do this with BioMart?