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Orthologues of the Schizosaccharomyces pombe Mcm6 gene

Go to the Ensembl Fungi site to find out the following:

  1. How many orthologues and how many paralogues are predicted for the Schizosaccharomyces pombe Mcm6 gene?

  2. How many Schizosaccharomyces orthologues are there?

  3. Does it have a human orthologue? If so what type is it and what is the orthologue’s Ensembl ID?

  1. From the Ensembl Fungi homepage, select Schizosaccharomyces pombe from the Favourite genomes section and search for Mcm6 in the species information page. Alternatively, you can select S. pombe from the Species search drop-down and enter Mcm6. In the search results, click on the gene ID SPBC211.04c to open the Gene tab. Click on Fungal Compara: Orthologues in the left-hand menu to see all the orthologous genes. You can find the number of orthologues and paralogues of the gene in the summary information at the top of the page.

    Mcm6 has 387 orthologues and 4 paralogues.

  2. Use the filter in the top right-hand corner of the table to search for Schizosaccharomyces.

    There are 3 Schizosaccharomyces orthologues: Schizosaccharomyces cryophilus, Schizosaccharomyces japonicus and Schizosaccharomyces octosporus.

  3. Go to Pan-taxonomic Compara, hide the summary table and search for human in the Orthologues table.

    Yes, it is a 1:1 orthologue to the human FH gene (ENSG00000091483).