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Regulatory features in human

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Regulatory features in human

  1. Search for the regulatory feature ENSR00000262400. What type of feature is this? What is its genomic location?

  2. Which cell types is this feature inactive and/or repressed in? View the supporting evidence for the repressed cell type. What project was the repressed cell type studied in?

  3. Why do so many cells have this feature listed as NA on the Activity display?

  1. Search for ENSR00000262400 on the Ensembl homepage. Click on the search result to open the Regulation tab.
    ENSR00000262400 is a CTCF binding site found at Chromosome 11: 1,998,001 - 2,001,400, which can be found at the top of the Activity page.

  2. Scroll down to see the summary of regulatory activity across different cell types.
    The CTCF binding site is inactive in H1-hESC_3 and HepG2 cells. It is repressed in A673.

    Click on Source Data at the top of the page or in the left-hand menu. Use the filter at the top right-hand corner of the table and enter A673. You can find the source of the supporting evidence under the Source column. The cell type A673 was studied in the ENCODE project.

  3. Note that many cell types have this feature represented as NA. This is because no corresponding CTCF signal or peaks are available for these cell types as they were not studied in the project sources.
    Cells which do not have CTCF ChIP-seq data cannot have an activity listed for this feature.